While it is possible it's a coincidence, the number of 160k LS engines running just fine and then 2 dropping compression and failing in short order makes me think its a related issue vs bad luck of the draw. Rick and Huck are probably on to something, look at what was in common with the two engines. If the same fuel rail was used, that seems like a good start. It might be possible the injector is stuck open and causing issues, might be restricted and running lean enough to burn up a piston. If you don't want to invest in a new, tested set, at least swap in a different set from a known running engine, and/or soak yours in SeaFoam to clean them up a little. Run compression test on everything if you can, and pull valve covers to see if all the valves are moving reasonably.
And what else is in common? Harness could cause injector issues, if you didn't mess with timing chain and/or rockers, then I don't think that can realistically be the problem. If you have a different intake, you might try that as well (if it was the same factory intake). Look at what changed vs what didn't change and I'm guessing you'll find a smoking gun somewhere.