There is a set amount of torque required to keep the vehicle at a constant speed. HP is the amount of torque being applied over a distance(RPM). HP means nothing in this case. There is a curve in the engine where BSFC(Brake specific fuel consumption) is best, this means that there is an RPM and throttle position at which the engine produces the most power with the least amount of fuel. For max efficiency, you want the engine to be in that band when cruising. RV cams generally increase fuel economy and torque under the curve because they are focused on maximum efficiency at low RPM's where the engine spends most of its life around town and when towing.
There are two sides of this to consider. The amount of power needed to accelerate and keep the vehicle moving(which is a direct reflection of weight, parasitic losses in drivetrain, aerodynamic coefficent, and engine efficiency) and also the specific characteristics of the engine.
Weight difference between 88 Blazer(~4500lbs) and 86 K3500 CC(~7000lbs) is significant
Parasitic loss between 1/2-ton and 1-ton drivetrain is significant. I would expect a 15% loss in the 1/2 ton and maybe up to 30% in the 1-ton
The difference in aerodynamic coefficient between an 88 Blazer, 86 K3500 CC, and GMT400 are probably not large.
Engine efficiency differenced are going to be a total toss-up, especially once you start messing with cams, EFI or carb, tire size, transmission and rear end gearing. Since you don't have a solid understanding of what you are trying to do, you are just as likely to get right into the sweet spot of power and efficiency as you are to be completely outside of it.
I view anecdotal MPG claims the same way I view hunting, fishing, and dating stories... they are almost always wildly overexaggerated.
I'm a engineer by trade and my degree focused on propulsion, so I'm always interested in reading stuff like this. Here's a pretty good scientific breakdown on what you are actually looking at with the relationship between RPM, Power, Force, and fuel consumption.
https://takemebeyondthehorizon.word...part-3b-brake-specific-fuel-consumption-bsfc/
There are some good graphs in there showing just how often a vehicle driving around town ends up in a very low efficiency section.