What kind of transmission do you have? What do you use the truck for? What kind of driving do you typically do with it?
In my case, I have a 3 speed + granny low SM465 manual. I use my truck for towing, so I want to keep the manual, and the SM465 is known for its strength and reliability. I have heard that the NV4500 is a good transmission, but you would be looking at the same problem going from the SM465 to the NV4500, which is the dimensions are not the same. So you would still be stuck with drive shaft modifications, relocating the cross member, etc. Additionally (in my case) I would have to get a completely different bellhousing, and maybe even clutch kit (I havent looked that far into it). Not to mention, a new transmission is more expensive than the Ranger Torque Splitter. The Gear Vendors option is about equivalent to a new transmission, maybe a little more expensive.
Im not extremely well versed in the world of GM automatic transmissions, but if you have an automatic, i think for the cost of the gear vendors unit, you could probably put a pretty well built and bulletproof 4L80E in your truck and be in a good spot. My buddy is getting ready to purchase a Monster Transmission's 4L80E for his 6.5 TD dually which he uses for towing. And i believe it is close to half the cost of the gear vendors overdrive unit.