Yes, but the Q-jet primaries are tiny for great throttle response, and the secondaries open just enough the satisfy engine demand, which is not 100% open on a 350. That was the beauty of those carbs. You could probably put one on a 265 and it would work just fine running around on the tiny primaries, with the secondaries partially opening when needed. And then with some jetting changes, put it on a 400.
The Edelbrock 750 is a different animal. Its primaries are slightly smaller than the secondaries, but are larger than the Edelbrock 600 carb's primaries. So, the 600 will have crisper throttle response. That's a fact, Jack. And the 600's secondaries will probably never fully open, unless were talking about a 6,000 RPM engine with >90% VE. For reference, the 7,000 RPM 365hp/327 used a 585 CFM Holley, as did the base 390hp/427. It's simply a function of RPM, cubic inches, and VE.
That said, I think the new 650 Edlebrock AVS2 series would be my choice the the OP's engine. With its annular boosters and air valve adjustment it would blow away the antique 750 in every category. About that engine, what are the cam specs?