Totally Wrong , crazyoffroad. It's all about volumetric efficiency of the motor. I built a 454 quench motor (454) in a 74 , 6" lift , long bed , with a jet (q-jet carb) , 9.75 to 1 comp , big oval port heads (L-89 closed chamber), 268h comp cam , 4sp trans , 36" tires , 4.11 gears , that got better mph. than my wifes 97 4runner , (15-17 mph) , problably because you could leave in in 4th and cruz up hill , down hill and never move your foot on the skinny petal and never had to open the seondairy's on the q-jet.It would drag around 350's like honda's as far as power and torque.So I would not dish the 454 , it's way better than the 350 in every way if you build it right , in a truck. If you are going with crate motor's or running late model tbi motor's they all suck for mpg. and power , IMO. 350 with o/d vs. 454 with o/d , 350 get's better mpg's ? not true , IMO , for properly built motor's.