I'll tell you what I did.
First, I got a wideband meter (I got the NGK) that was not a "bolt it into the dash" kind of thing, but something I could hook up and set on the dash while I drove and tuned for a couple weeks, then take off once I was set. Once you have it set up, it is pretty much a done deal.
Then I hooked it up and just drove the truck normally, with half an eye on the readings. With the Edelbrock 1406, I was lean at cruise, rich in power, spot on in the secondaries, and rich at idle. Also, the cruise to power circuit transition was way late, because it is run by vacuum and these engines when cammed for torque pull a lot of vacuum.
So I replaced the pop-up springs in the Edelbrock to get the cruise to power transition to occur at a higher vacuum level so it would kick in sooner when I got on it.
Then I bought a whole bunch of rods from JEGS with the understanding I could return anything that was unopened. From the Edelbrock tuning chart in the manual, I had to go rich on the cruise (up in the chart) and lean in the power (left on the chart), so I picked a tune point and set it up like that. I ended up going two sizes smaller on the primary jet and changing the rods, per the chart, and got pretty close on the AFR, then played with different rods.
Finally, I leaned out the idle to spec. The numbers I aimed at are 13.5 idle, 14.5 cruise, 13.5 power, and 12.5 secondaries, and I hit them spot on. My gas mileage went up 20%, and my power and smoothness of power delivery and throttle response all improved markedly over the stock tune.
Why 13.5 on idle? Because at the very low stack velocity through the carb at idle, the mixture going into the manifold is not completely uniform, and if the charge any cylinder gets is over about 17:1, it will miss. So an average AFR of 13.5:1 means no cylinder will ever see over 17:1, and you will get a smooth idle under a wide range of conditions.