If you want off-idle to 4500, you can go with the Comp 12-300-4 cam and get 422 lbft at 2500 rpm and have 300+ from 1000 on up. That's what I did, and I love it. No winding up over 4500, though. Changing the tranny governor by going one size heavier on one weight moves the shift points down 500 rpm to make best use of it.
With that much whoopee in the bottom, I wouldn't mess with the rear end. Just keep the short tires on it. I have 31" tires and G80 limited slip on a 3.78:1, and punching it off the stop -- no brake-torquing or anything, just punching it -- will break the rears loose. If you keep 29s on it, or even go smaller, which will lower it a bit too, you will have plenty out of the hole. 27" tires are still pretty good size compared to auto tires. 27s with the 3.08:1 would be like the 29s with 3.3:1. Cheap gear change.
Weiand (no relation) makes good intakes, but I haven't used one since the 1970s, so my experience with them is dated. The Edelbrock dual-plane manifolds are good, though.
Supercharging I know nothing about. Bear in mind though, that the highest-torque engine GM put the TH350 on had 410 lbft of torque. If you are planning on going higher than the 422 lbft you can get with the 12-300-4 cam, you need to be rethinking the whole drivetrain, and getting beefed up components, including the suspension.
700R4s can be persnickety. They have to be set up right. So be careful doing that. The early ones are junk compared to the TH350. And the 700R4 doesn't like to be lugged, so you are probably going to have to change gears if you go that route.
The Qjet is the better carb, but it is harder to tune. The way to go about it is not to buy one off the shelf, but get one made up for the setup you are building. Talk to Sean Murphy at SMI, and he will tune you one up to match your build for about what an off-the-shelf one would cost you.